Benzopyran compound

Details Benzopyran compound Benzopyran compound

C - Chemistry, Metallurgy

07

D

C07D 311/68 (2006.01) A61K 31/353 (2006.01) A61P 9/06 (2006.01)

Patent

CA 2557395

This invention relates to benzopyran compounds of formula (I) wherein X is NR6, Y is a bond, SO or SO2, Z is C1-4alkyl group or phenyl group, W is hydrogen atom, hydroxy group, C1-6 alkoxy group, a halogen atom, C1-4alkyl group or C1-6alkylsulfonylamino group, R1 and R2 are independently of each other C1-3alkyl group, R3 is hydrogen atom, hydroxy group or methoxy group, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CR7R8, NR9, O, S, SO or SO2, R4 is hydrogen atom or C1-6alkyl group, R5 is hydrogen atom, C1-6alkyl group, C3-8cycloalkyl group, C3-8cycloalkenyl group, C6-14aryl group or C2-9heteroaryl group. These compounds are useful as an anti- arrhythmic agent.

Cette invention est relative à un composé de benzopyrane de formule (I) où X est NR?6¿, Y est une liaison, SO ou SO¿2?, Z est un groupe C¿1-4?alkyle ou un groupe phényle, W est un atome d~hydrogène, un groupe hydroxy, un groupe C¿1-6? alkoxy, un atome d~halogène, un groupe C¿1-4?alkyle ou un groupe C¿1-6?alkylsulfonylamino, R?1¿ et R?2¿ sont indépendamment l~un de l~autre un groupe C¿1-3?alkyle, R?3¿ est un atome d~hydrogène, un groupe hydroxy ou un groupe méthoxy, m est un entier de 0 à 4, n est un entier de 0 à 4, V est une liaison unique, CR?7¿R?8¿, NR?9¿, O, S, SO ou SO¿2?, R?4¿ est un atome d~hydrogène ou un groupe C¿1-6?alkyle, R?5¿ est un atome d~hydrogène, un groupe C¿1-6?alkyle, un groupe C¿3-8?cycloalkyle, un groupe C¿3-8?cycloalkényle, un groupeC¿6-14?aryle ou un groupe C¿2-9?hétéroaryle. Ce composé est utile en tant qu~agent anti-arythmie.

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