Benzopyran derivatives

Details Benzopyran derivatives Benzopyran derivatives

C - Chemistry, Metallurgy

07

D

167/208, 260/251

C07D 311/58 (2006.01) A61K 31/44 (2006.01) C07D 213/89 (2006.01) C07D 239/26 (2006.01) C07D 241/12 (2006.01) C07D 405/04 (2006.01)

Patent

CA 1334094

Compounds of the formula Image I wherein R1 represents hydrogen, halogen, trifluoro- methyl, nitro, cyano, lower alkyl, lower alkoxy- carbonyl, lower alkylthio, lower alkylsulphonyl, lower alkanoyl, aroyl, carbamoyl, mono(lower alkyl)carbamoyl or di(lower alkyl)carbamoyl, R2 represents hydrogen, lower alkyl or phenyl, R3 represents hydrogen or lower alkyl, R4 and R5 each represent hydrogen or R4 represents hydroxy and R5 represents hydrogen or R4 and R5 together represent a carbon-carbon bond and R6 represents an aryl or N-heteroaryl group carrying a hydroxy group in the 2-position or, in the case of a N-heteroaryl group, also a N-oxide group in the 2-position, and pharmaceutically acceptable acid addition salts of these compounds of formula I which are basic, possess pronounced potassium channel activating activity and can be used as medicaments, particularly in the control or prevention of hypertension, congestive heart failure, angina pectoris, peripheral and cerebral vascular disease and smooth muscle disorders.

571115

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