Benzopyran derivatives having anti-hypertensive and...

Details Benzopyran derivatives having anti-hypertensive and... Benzopyran derivatives having anti-hypertensive and...

C - Chemistry, Metallurgy

07

D

C07D 405/04 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2053928

ABSTRACT OF THE DISCLOSURE Compounds of formula (I): Image (I) in which: R1 is perfluoroalkyl; R2 is a group of formula (II): Image (II) in which R4 is hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, cyano, hydroxy or nitro; or a group of formula (III): Image (III) in which R5 is hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, cyano or nitro; .alpha.-.beta. is a carbon-carbon single bond or a carbon-carbon double bond; and where .alpha.-.beta. is a carbon-carbon single bond, R3 is hydroxy or nitrooxy or, where .alpha.-.beta. is a carbon-carbon double bond, R3 is hydrogen; and pharmaceutically acceptable salts thereof, have valuable anti-hypertensive activity and can thus be used for the treatment and prophylaxis of cardiovascular diseases. The invention also provides methods and compositions using these compounds as well as processes for their preparation.

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