Benzopyran derivatives having leukotriene-antagonistic action

Details Benzopyran derivatives having leukotriene-antagonistic action Benzopyran derivatives having leukotriene-antagonistic action

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/35 (2006.01) A61K 31/38 (2006.01) A61K 31/41 (2006.01) A61K 31/47 (2006.01) C07D 311/22 (2006.01) C07D 311/24 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 407/00 (2006.01) C07D 409/00 (2006.01)

Patent

CA 2249402

The present invention relates to novel benzopyran derivatives of formula (I), wherein A is an oxygen or sulfur atom or a methylene group; B and C are: a) when B is a benzofused heterocycle (a) wherein U is an O, S or N atom, Z-Y are two carbon atoms linked by a double or single bond and T is a single bond, a methylene or carbonyl group, C can be a -CONR7-, CSNR7-, -SO2NR7-, -CH2O-, -CH=CH- group; b) when B is a phenyl group (b), C can be a -SO2NR7-, -CH2O-, -CH=CH- group; D is a 5-tetrazolyl or -COOR8 group, wherein R8 is hydrogen, a (C1-C4)-alkyl or phenylalkyl group; and m and n are integers between 0 and 4. Said compounds show a leukotriene-antagonistic activity, and they are valuable as anti-inflammatory and antiallergic medicaments or in the treatment of cardiovascular diseases.

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