C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/04 (2006.01)
Patent
CA 2527132
The present invention relates to benzopyran derivatives substituted with a thioxobenzoxazole derivative, or pharmaceutically acceptable salts thereof, processes for preparing the same and a pharmarceutical composition containing the above as an effective ingredient. Benzopyran derivatives substituted with thioxobenzoxazole derivatives, represented in <Formula 1>, (see formula 1) (wherein, R1, R2, R3, R4, R5 and * are as defined in the description) have the function of protecting heart from ischemia-reperfusion both in vivo and in vitro, so that a pharmaceutical composition containing benzopyran derivatives substituted with thioxobenzoxoazole derivatives or pharmaceutically acceptable salts thereof of the present invention as an effective ingredient can be effectively used for the protection of tissues influenced by ischemia-reperfusion, for example, for the protection of heart, nervous cells, brain, retinal cells, storage organs, etc, and for the treatment of diseases caused by ischemia-reperfusion.
L'invention concerne des dérivés de benzopyrane substitués par un dérivé de thioxobenzoxazole, y compris des sels pharmaceutiquement acceptables correspondants, des procédés de préparation correspondants, et une composition pharmaceutique contenant ces produits comme principe actif. Ces dérivés, de formule 1, protègent le coeur contre l'ischémie-reperfusion in vivo et in vitro, si bien qu'une composition pharmaceutique les contenant comme principe actif, y compris les sels susmentionnés, peut être utilisée efficacement pour la protection des tissus affectés par l'ischémie-reperfusion, par exemple pour la protection du coeur, des cellules nerveuses, du cerveau, des cellules de la rétine, des organes de stockage, etc., et pour le traitement des maladies résultant de l'ischémie-reperfusion.
Hwang Sun Kyung
Kim Nak Jeong
Kim Sun Ok
Kim Tae Mi
Lee Byung Ho
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Dongbu Hannong Chemical Co. Ltd.
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