Benzopyranopyrrole and benzopyranopyridine alpha-1...

Details Benzopyranopyrrole and benzopyranopyridine alpha-1... Benzopyranopyrrole and benzopyranopyridine alpha-1...

C - Chemistry, Metallurgy

07

D

C07D 491/04 (2006.01) A61K 31/415 (2006.01)

Patent

CA 2272330

The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are .alpha.-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 adrenoreceptors and treating BPH.

La présente invention concerne un composé de la formule (I) ainsi que les sels de celui-ci, acceptables sur le plan pharmacologique. Dans cette formule W représente un système de noyau hétérocyclique bicyclique. Ces composés sont des antagonistes .alpha.-1 adrénergiques et ils sont utiles dans le traitement de l'hyperplasie prostatique bénigne. L'invention concerne également des compositions antagonistes .alpha.-1 adrénergiques ainsi qu'un procédé destiné à antagoniser les adrénorécepteurs .alpha.-1 et à traiter l'hyperplasie prostatique bénigne.

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