Benzoquinazoline compounds

Details Benzoquinazoline compounds Benzoquinazoline compounds

C - Chemistry, Metallurgy

07

D

C07D 239/70 (2006.01) A61K 31/505 (2006.01) A61K 38/04 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07K 5/04 (2006.01)

Patent

CA 2085589

Compounds of formula (I) or salts thereon; wherein the dotted line represents a single or double bond, R1 is alkyl or ami- no optionally substituted by alkyl, alkanoyl or benzyl group; R2, R3, R4 and R5 are the same or different and each is select- ed from hydrogen, phenyl, halo, nitro, a group S(O)n R8 wherein n is the integer 0, 1 or 2 and R8 is halo or alkyl or a group NR9R10 wherein R9 and R10 are both hydrogen, a group NR11R12 wherein R11 and R12 are the same or different and each is hydrogen or alkyl, a group OR13 wherein R13 is hydrogen or C1-4 of alkyl optionally substituted by halo; a C1-4 aliphatic group optionally substituted by a group OR14 or NR14R15 wherein R14 and R15 are the same or different and each is hydrog- en or alkyl; or two of R2 to R5 are linked together to form a benzo group; or one of R2 to R5 is a group X-Y-R16 wherein X is CH2, NR17, CO or S(O)m and Y is CH2, NR17, O or S(O)m, or X-Y is O, NR17, -CH= CH- or N=N-; are disclosed as phar- macological agents useful in the treatment of tumours. Pharmaceutical compositions and methods for the preparation of compounds of formula (I) are also described.

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