Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate

Details Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate

C - Chemistry, Metallurgy

07

D

C07D 455/04 (2006.01) A61K 31/4375 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2537066

The invention relates to crystalline S-(-)-9-fluoro-6,7-dihydro-8-(4- hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid L-arginine salt tetrahydrate, a process for its preparation and pharmaceutical formulations incorporating it as the active ingredient for use in treating microbial infections.

L'invention concerne un sel cristallin de L-arginine tétrahydrate d'acide S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypipéridin-1-yl)-5-méthyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylique, son procédé de préparation et des préparations pharmaceutiques utilisant comme ingrédient actif ce sel, destinées au traitement d'infections microbiennes.

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