Benzoquinone antiallergy and antiinflammatory agents

C - Chemistry – Metallurgy – 07 – C

Patent

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C07C 225/28 (2006.01) A61K 31/00 (2006.01) C07C 229/14 (2006.01) C07C 229/42 (2006.01) C07C 229/48 (2006.01) C07C 229/56 (2006.01) C07C 235/80 (2006.01) C07C 237/20 (2006.01) C07C 311/39 (2006.01) C07D 213/74 (2006.01) C07D 307/02 (2006.01) C07D 307/14 (2006.01) C07D 307/52 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2034596

72222-164 ABSTRACT OF THE DISCLOSURE A series of 2-amino-5,6-dimethyl-1,4-benzoquinone derivatives, of the formula: Image (I) [wherein R1 is H, alkyl, cycloalkyl, phenylalkyl, acyl or CH(OZ)R8 (where R8 is H, alkyl, carboxyalkyl or alkoxycarbonyl- alkyl and Z is H or methoxyethoxymethyl); R2 is H or phenyl; and R3 is cycloalkyl, cycloalkylalkyl, a group Image (where m is 0 to 3 and R5 and R6 are possible substituents) or R7 alkyl (where R7 is hydroxyl, carboxyl, alkoxycarbonyl, hydroxy- alkoxy or furyl) or R2 and R3 together with the adjacent nitrogen atom form Image are inhibitors of cyclooxygenase and lipoxy- genase and are useful as antiallergic and antiinflammatory agents.

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