Benzoquinone derivatives and production thereof

Details Benzoquinone derivatives and production thereof Benzoquinone derivatives and production thereof

C - Chemistry, Metallurgy

07

H

167/179, 260/308

C07H 5/04 (2006.01) C07C 43/315 (2006.01) C07C 47/277 (2006.01) C07C 47/575 (2006.01) C07C 50/38 (2006.01) C07C 59/64 (2006.01) C07C 59/68 (2006.01) C07C 66/00 (2006.01) C07C 217/62 (2006.01) C07D 295/08 (2006.01) C07D 295/096 (2006.01) C07D 295/116 (2006.01) C07H 13/04 (2006.01)

Patent

CA 1242708

Abstract of the Disclosure Novel benzoquinone derivatives are disclosed of the general formula: (I) Image [wherein R1 and R2 are the same or different and each is methyl or methoxy; n is zero or an integer of up to 21; m is 0 or 1, Z is a group of the formula: Image (wherein R3 and R4 are the same or different and each is hydrogen or an alkyl group which may optionally be substituted or, R3 and R4 together with the adjacent nitrogen atom form a morpholino group), a group of the formula: -COR5 (wherein R5 is an .alpha.-amino acid residue or a substituted or unsubstituted glucosamine residue), a group of the formula: Image (wherein R6 is a divalent hydrocarbon group of 1 to 3 carbon atoms), a group of the formula: Image 6-COOH (wherein R6 has the same meaning as defined above) or a group of the formula: Image (wherein ? is an integer of 1 to 4 and R7 is hydroxy, methoxy or methyl)]. The compounds (I) have protocollagen-proline hydroxylase inhibiting activity, collagen biosynthesis inhibiting activity and 5-lipoxygenase suppressant activity, and are useful for the prevention and treatment of such diseases as pulmonary fibrosis, hepatocirrhosis, nephrosclerosis, arteriosclerosis, scleroderma, myelofibrosis and chronic arthritis or for the prevention and treatment of asthma, allergic rhinitis or urticaria.

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