C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/55 (2006.01) A61P 11/08 (2006.01) C07D 221/00 (2006.01) C07D 337/00 (2006.01)
Patent
CA 2396962
This invention provides novel benzosulfones of formulae (I) and (II). These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders.
L'invention concerne de nouveaux benzosulfones représentés par les formules (I) et (II). Ces composés sont utilisés comme antagonistes des canaux calciques et possèdent une activité cardiovasculaire, antiasthmatique et antibronchoconstrictrice. Cette invention concerne également des compositions pharmaceutiques, ainsi que des méthodes de prévention et de traitement de troubles tels que l'hypersensibilité, l'allergie, l'asthme, les bronchospasmes, la dysménorrhée, les spasmes de l'oesophage, les glaucomes, l'accouchement prématuré, les troubles urinaires, les troubles de motilité gastrointestinale et les troubles cardiovasculaires.
Bullington James L.
Dodd John H.
Hall Daniel A.
Rupert Kenneth C.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ortho-Mcneil Pharmaceutical Inc.
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