Benzothia(dia)zine derivatives and their use as ampa modulators

Details Benzothia(dia)zine derivatives and their use as ampa modulators Benzothia(dia)zine derivatives and their use as ampa modulators

C - Chemistry, Metallurgy

07

D

C07D 279/02 (2006.01) A61K 31/5415 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2471057

The invention concerns compounds of formula (I), wherein: R¿1? represents a hydroxy group or a RCO-O- group; R¿2? represents a hydrogen, halogen atom, a hydroxy group or a R'CO-O group; R, R', identical or different, represent an optionally substituted alkyl group; R¿3? represents a hydrogen atom, an alkyl group or a cycloalkyl group; A represents a CR¿4?R¿5? group or a NR¿4? group; R¿4? represents a hydrogen atom or an alkyl group; their isomers and their addition salts to a pharmaceutically acceptable acid or base. Said compounds are useful as AMPA modulators for treating or preventing memory and learning disorders associated with age, anxiety or depression syndromes, gradual neurodegenerative diseases, Alzheimer's disease, Pick's disease, Huntington's chorea, schizophrenia, sequels of acute neurodegenerative diseases, ischemia sequels and epilepsy sequels.

Composés de formule (I) dans laquelle R1 représente un groupement hydroxy ou un groupement RÇO-O-, R2 représente un atome d'hydrogène, d'halogène, un groupement hydroxy ou un groupement R'CO-O, R, R', identiques ou différents, représentent un groupement alkyle éventuellement substitué, R3 représente un atome d'hydrogène, un groupement alkyle ou un groupement cycloalkyle, A représente un groupement CR4R5 ou un groupement NR4, R4 représente un atome d'hydrogène ou un groupement alkyle, leurs isomères ainsi que leurs sels d'addition à un acide ou à une base pharmaceutiquement acceptable. Ces composés sont utiles en tant que modulateurs AMPA pour le traitement ou la prévention des désordres mnémocognitifs associés à l'âge, aux syndromes anxieux ou dépressifs, aux maladies neurogénératives progressives, à la maladie d'Alzheimer, à la maladie de Pick, à la chorée d'Huntington, à la schizophrénie, aux séquelles des maladies neurodégénératives aiguës, aux séquelles de l'ischémie et aux séquelles de l'épilepsie.

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