C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 285/36 (2006.01) A61K 31/554 (2006.01) A61P 3/06 (2006.01) A61P 3/08 (2006.01)
Patent
CA 2483155
The present invention relates to compounds of formula (I): wherein Rv,R1, R2, RX, RY, R3, R4, R5, R6, RZ and v are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.
L'invention concerne des composés de formule (I). Dans cette formule, R?v¿, R?1¿, R?2¿, R<SP>X</SP>, R<SP>Y</SP>, R?3¿, R?4¿, R?5¿, R?6¿, R<SP>Z</SP> et v sont tels que défini dans la description. L'invention concerne également des sels, des solvates et des solvates de ces sels ainsi que des promédicaments de ces composés acceptables sur le plan pharmaceutique, et leur utilisation en tant qu'inhibiteurs du transport de l'acide biliaire iléal (IBAT) servant au traitement de l'hyperlipidémie. L'invention concerne enfin des procédés destinés à la préparation de ces composés et des compositions pharmaceutiques les contenant.
Alenfalk Suzanne
Bostrom Stig Jonas
Dahlstrom Mikael Ulf Johan
Nordberg Mats Peter
Starke Ingemar
Astrazeneca Ab
Fetherstonhaugh & Co.
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