C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 285/36 (2006.01) A61K 31/19 (2006.01) A61K 31/40 (2006.01) A61K 31/554 (2006.01) A61P 3/06 (2006.01) C07D 281/02 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2459449
The present invention relates to compounds of formula (I) wherein Rv, R1, R2, Rx, Ry, M, Rz, v, R3, R4, R5 and R6 are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.
La présente invention se rapporte à des composés représentés par la formule (I), où R?v¿, R?1¿, R?2¿, R?x¿, R?y¿, M, R?z¿, v, R?3¿, R?4¿, R?5¿ et R?6¿ sont définis dans le descriptif de l'invention. L'invention a également trait à des sels acceptables sur le plan pharmaceutique, des solvates, des solvates desdits sels et des promédicaments faisant appel à ceux-ci, et à leur utilisation en tant qu'inhibiteurs du transport des acides biliaires iléaux (IBAT) pour le traitement de l'hyperlipidémie. L'invention a également trait à leurs procédés de fabrication et à des compositions pharmaceutiques les contenant.
Alenfalk Suzanne
Blomberg David
Dahlstrom Mikael Ulf Johan
Lemurell Malin
Skjaret Tore
Albireo Ab
Astrazeneca Ab
Fetherstonhaugh & Co.
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