Benzothiazepine derivatives

Details Benzothiazepine derivatives Benzothiazepine derivatives

C - Chemistry, Metallurgy

07

D

167/209, 260/238

C07D 281/10 (2006.01) A61K 31/55 (2006.01) C07D 417/06 (2006.01)

Patent

CA 1338417

Calcium channel blocking activity is exhibited by compounds having the formula Image or a pharmaceutically accpetable salt thereof, wherein the stereochemistry at the chiral centers in the 2 and 3-positions of the benzo- thiazepine nucleus is cis, and wherein R1 is alkyl, aryl, arylalkyl, alkenyl or alkynyl; R2 and R5 are each independently hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen or trifluoromethyl; and R3 and R4 are each independently alkyl or cycloalkyl or R3 and R4 together with the nitrogen atom to which they are attached are pyrrolidinyl, piperidinyl or morpholinyl.

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