Benzothiazepine derivatives for the treatment of hyperlipidemia

Details Benzothiazepine derivatives for the treatment of hyperlipidemia Benzothiazepine derivatives for the treatment of hyperlipidemia

C - Chemistry, Metallurgy

07

D

C07D 281/10 (2006.01) A61K 31/554 (2006.01) A61K 38/05 (2006.01) A61P 3/06 (2006.01) C07K 5/06 (2006.01)

Patent

CA 2459457

The present invention relates to compounds of formula (I): wherein variable groups are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.

L'invention concerne des composés représentés par la formule (I) dans laquelle différents groupes sont tels que définis dans le descriptif. L'invention concerne par ailleurs des sels acceptables sur le plan pharmaceutique, des solvates, des solvates desdits sels, des promédicaments de ces composés ainsi que leur utilisation comme inhibiteurs du transport des acides biliaires iléaux (IBAT) dans le traitement de l'hyperlipidémie. L'invention concerne également des procédés préparation de ces composés ainsi que des compositions pharmaceutiques qui les renferment.

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