Benzothiazepine esters, their preparation and formulations...

Details Benzothiazepine esters, their preparation and formulations... Benzothiazepine esters, their preparation and formulations...

C - Chemistry, Metallurgy

07

D

C07D 281/10 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2044834

- 16 - A B S T R A C T NOVEL BENZOTHIAZEPINE ESTERS, THEIR PREPARATION AND FORMULATIONS FOR THERAPEUTIC USE A class of benzothiazepine esters having structures related -to that of diltiazem are provided which possess vasodilating activity while being virtually free of cardiodepressive effects. The esters are useful in the treatment of arterial hypertension and disturbances of the cerebral circulation. The compounds have the general formula I Image herein R represents hydrogen or an electronegative group (preferably a halogen atom~ or a nitro, trifluoromethyl or methoxy group); and X is a hydrocarbyl group containing from 1 to 15 carbon atoms.

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