Benzothiazine derivatives, a process for their preparation,...

Details Benzothiazine derivatives, a process for their preparation,... Benzothiazine derivatives, a process for their preparation,...

C - Chemistry, Metallurgy

07

D

260/243.25

C07D 279/16 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 1251791

- 1 - Abstract of the disclosure: The invention relates to benzothiazine deriva- tives of the formula I Image (I) with R(1), R(1)' and R(1)" equal to hydrogen, (C1-C4)- alkyl, (C1-C3)-alkoxy, halogen, nitro, hydroxyl, acet- amido or amino; R(2) equal to hydrogen, (C1-C10)-alkyl, (C3-C10)-alkenyl, phenyl, optionally substituted, R(3) equal to hydrogen, (C1-C10)-alkyl, (C3-C10)-alkenyl, phenyl, R(4) and R(4)' are identical or different and, independently of one another, equal to hydrogen, (C1-C4)- alkyl, (C1-C3)-alkoxy, halogen, nitro, hydroxyl, acet- amido or amino; R(5) equal to hydrogen or (C1-C3)-alkyl, R(6) equal to a part structure from the following group, Image in which R(7) and R(8) equal to hydrogen, alkyl, cycloalkyl, phenyl, R(9) equal to hydrogen, alkyl, phenyl, pyridyl, pyrimid- inyl or benzoyl, R(10) equal to hydrogen, alkyl, phenyl, - 2 - R(11) equal to hydrogen, hydroxyl, (C1-C4)-alkoxy or, together with R(12), a bond, and R(12) equal to hydrogen or, together with R(11), a bond, m equal to 1, 2, 3 or 4, n equal to 0 or 1, p equal to 0, 1, 2, 3 or 4, and X equal to oxygen or two hydrogen atoms. The invention also relates to salts of the com- pounds of the formula I with physiologically tolerated acids and to a process for the preparation of compounds I, likewise to their use for the treatment of disturb- ances of the calcium balance of a human body.

471072

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