Benzothiazine dioxides as endothelin antagonists

Details Benzothiazine dioxides as endothelin antagonists Benzothiazine dioxides as endothelin antagonists

C - Chemistry, Metallurgy

07

D

C07D 417/06 (2006.01) A61K 31/54 (2006.01) A61K 31/675 (2006.01) A61K 31/69 (2006.01) C07D 275/06 (2006.01) C07D 279/02 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07F 5/02 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2211027

Novel benzothiazine dioxides which are antagonists of endothelin are described, as well as novel intermediates used in their preparation, methods for the preparation, and pharmaceutical compositions of the same, which are useful in treating elevated levels of endohelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.

On décrit de nouveaux dioxydes de benzothiazine qui sont des antagonistes de l'endothéline ainsi que de nouveaux intermédiaires utilisés dans leur préparation, des méthodes pour leur préparation et des compositions pharmaceutiques contenant ces composés, qui sont utiles pour traiter les taux élevés d'endothéline, l'hypertension artérielle essentielle, réno-vasculaire, maligne et pulmonaire, l'infarctus, l'ischémie cérébrale, l'insuffisance cardiaque globale et l'hémorragie sous-arachnoïdienne.

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