Benzothiazole and benzothiophene derivatives

Details Benzothiazole and benzothiophene derivatives Benzothiazole and benzothiophene derivatives

C - Chemistry, Metallurgy

07

D

167/234, 167/242

C07D 277/62 (2006.01) C07D 277/68 (2006.01) C07D 333/52 (2006.01) C07D 333/56 (2006.01) C07D 333/58 (2006.01) C07D 333/60 (2006.01) C07D 333/70 (2006.01) C07D 495/04 (2006.01)

Patent

CA 1254216

BENZOTHIAZOLE AND BENZOTHIOPHENE DERIVATIVES. ABSTRACT The invention relates to compounds of the general formula I Image wherein R1 represents one up to and including four, the same or different substituents selected from alkyl(1-6 C), alkoxy(1-6 C), hydroxy, halogen, NO2, CF3 or the group -NR5R6, whereby two substituents taken together may also represent a methylene-dioxy group, X represents nitrogen or the group Image n has the value 0, 1 or 2, R3 represents one of the moieties: Image the latter meaning of R3 (amide) only under the condition that for X is nitrogen the meaning of R1 is limited to substituents selected from hydroxy, alkoxy(l- 6 C) and methylenedioxy, and R4, R5 and R6 represent hydrogen or alkyl(1-6 C), and pharmaceutically acceptable salts thereof, suitable in the treatment of heart failure.

476161

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