Benzothiazole compound, production thereof and use thereof

Details Benzothiazole compound, production thereof and use thereof Benzothiazole compound, production thereof and use thereof

C - Chemistry, Metallurgy

07

D

C07D 277/64 (2006.01) A61K 31/425 (2006.01) C07C 255/25 (2006.01) C07C 255/29 (2006.01) C07C 323/41 (2006.01)

Patent

CA 2136743

ABSTRACT OF THE DISCLOSURE Production of a benzothiazole compound of the formula (I) Image (I) wherein R1 is a halogen atom, R2 and R3 may be the same or different and each is a hydrogen atom or a halogen atom, R4 is a hydrogen atom, a halogen atom, a lower alkyl, an alkoxy or an alkyl mercapto and R5 is a hydrogen atom or a lower alkyl, or a pharmaceutically acceptable salt thereof. The compound of the formula (I) and a pharmaceutically acceptable salt thereof of the present invention have an aldose reductase inhibitory activity in mammals inclusive of human and have superior safety. Accordingly, they are useful as pharmaceutical compositions for the treatment of the complications of diabetes, such as faulty union of corneal injury, cataract, neurosis, retinopathy and nephropathy, particularly cataract and neurosis. 7 3

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