Benzothiazolythiomethyl carbapenem antibacterial

Details Benzothiazolythiomethyl carbapenem antibacterial Benzothiazolythiomethyl carbapenem antibacterial

C - Chemistry, Metallurgy

07

D

C07D 477/14 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2333620

The present invention relates to tricyclic carbapenem antibacterial agents in which the carbapenem nucleous is fused to a 6 membered carbocyclic ring. The compound is further substituted with various substituent groups including at least one cationic group. The compounds are represented by formula (I). Pharmaceutical compositions and methods of use are also included.

La présente invention concerne des agents antibactériens de carbapenem tricyclique, dans lesquels le noyau de carbapenem est condensé avec un noyau carbocyclique à 6 chaînons. Les composés de cette invention sont par ailleurs substitués par divers substituants, dont au moins un groupe cationique, ces composés étant représentés par la formule (I). Cette invention concerne également des compositions pharmaceutiques et leurs méthodes d'utilisation.

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