Benzothieno[3,2-c]pyridines as .alpha.2 antagonists

Details Benzothieno[3,2-c]pyridines as .alpha.2 antagonists Benzothieno[3,2-c]pyridines as .alpha.2 antagonists

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2346084

The present invention concerns the compounds of formula (I), the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein each R1 is independently hydrogen, halogen, C1-6 alkyl, nitro, hydroxy or C1-4 alkyloxy; Alk is C1-6 alkanediyl; n is 1 or 2; p is 0, 1 or 2; D is an optionally substituted mono-, bi- or tricyclic nitrogen containing heterocycle having central .alpha.2-adrenoceptor antagonist activity. It further relates to their preparation, compositions comprising them and their use as a medicine.

La présente invention concerne des composés représentés par la formule générale (I), certains de leurs N-oxides, certains de leurs sels d'addition pharmaceutiquement admis, et leurs formes stéréochimiquement isomères. En l'occurrence, chaque R<1> est indépendamment hydrogène, halogène, C1-C6 alkyle, nitro, hydroxy ou C1-C4 alkyloxy. Alk est C1-C6 alkanediyle. "n" vaut 1 ou 2. "p" vaut 0, 1 ou 2. Enfin, D est un azote monocyclique, bicyclique ou tricyclique éventuellement substitué contenant un hétérocycle présentant une activité centrale antagoniste de l' alpha 2-adrénocepteur. L'invention concerne en outre la préparation de ces composés, des compositions les contenant et leur utilisation comme médicament.

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