Benzothiepino[5,4-c]pyridazine compounds and their...

Details Benzothiepino[5,4-c]pyridazine compounds and their... Benzothiepino[5,4-c]pyridazine compounds and their...

C - Chemistry, Metallurgy

07

D

167/224, 260/264

C07D 495/04 (2006.01) A61K 31/50 (2006.01)

Patent

CA 1321201

Y01-49919C/NK/88 ABSTRACT OF THE DISCLOSURE A benzothiepino[5,4-c]pyridazine compound of the formula: Image wherein R1 and R2 are the same or different and each is hydrogen, halogen, trifluoromethyl, hydroxy, amino, nitro, cyano, C1-4 alkyl, C1-4 alkoxy, or C2-5 alkanoylamino, R3 is hydrogen, C1-8 alkyl, hydroxy-C1-4 alkyl, C2-5 alkanoyloxy-C1-4 alkyl, aryl, aryl-C1-4 alkyl, heteroaryl, or substituted aryl, aryl-C1-4 alkyl or heteroaryl by 1 to 3 substituents selected from the group consisting of halogen, trifluoromethyl, hydroxy, amino, nitro, cyano, C1-4 alkyl, C1-4 alkoxy and C2-5 alkanoylamino on the aromatic ring, n is 0, 1 or 2, and the bond ---- between the 4-position and the 4a-position is single bond or double bond. Said compounds exhibit anti-anxietic activity and are useful as anti-anxiety agent.

560227

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