C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/12 (2006.01) A61K 31/381 (2006.01) A61K 31/4025 (2006.01) A61K 31/4535 (2006.01) A61K 31/5377 (2006.01) A61P 5/30 (2006.01) A61P 9/00 (2006.01) A61P 19/10 (2006.01) C07D 333/52 (2006.01) C07D 333/62 (2006.01) C07D 333/64 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2170479
The present invention provides pharmaceutically active compounds of formula I (see formula I) wherein R1 is -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), or -OSO2(C2-C6 alkyl); R2 is -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), -OSO2(C2-C6 alkyl), or halo; R3 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1- pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1--hexamethyleneimino; n is 2 or 3; and z is -O- or -S-; or a pharmaceutically acceptable salt thereof. Further provided are pharmaceutical compositions of compounds of formula I.
Palkowitz Alan David
Thrasher Kenneth Jeff
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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