Benzothiophenes and benzofurans as agents of therapeutic use...

A - Human Necessities – 61 – K

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Details

A61K 31/41 (2006.01) A61K 31/42 (2006.01) G01N 30/00 (2006.01) G01N 33/493 (2006.01)

Patent

CA 2163542

This instant invention is novel uses of known benzothiophenes or benzofurans and pharmaceutically salts thereof. Such compounds as 5-methoxy-3-(1-methylethoxy)-N-1H-tetrazol-5-ylbenzo[b]thiophene-2-carboxamide is used for treating inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. The instant invention is also an assay for noninvasively monitoring inflammation.

L'invention porte sur de nouvelles utilisations de benzothiophènes et de benzofuranes connus et de leurs sels pharmacocompatibles. De tels composés tels que le 5-méthoxy-3-(1-méthyléthoxy)-N-1H-tétrazol-5-ylbenzo[b]thiophène-2-carboxamide sont utilisés dans le traitement d'états inflammatoires de l'intestin tels que la maladie de Crohn et les colites ulcérantes. Cette invention sert aussi de test non invasif de diagnostic des inflammations.

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