Benzothiophenes and benzofurans having antiallergy activity

Details Benzothiophenes and benzofurans having antiallergy activity Benzothiophenes and benzofurans having antiallergy activity

C - Chemistry, Metallurgy

07

D

167/233, 260/304

C07D 405/02 (2006.01) A61K 31/41 (2006.01) C07D 307/85 (2006.01) C07D 307/86 (2006.01) C07D 307/92 (2006.01) C07D 333/70 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 409/02 (2006.01) C07D 409/04 (2006.01) C07D 409/12 (2006.01) C07D 495/04 (2006.01)

Patent

CA 1261848

ABSTRACT Novel benzothiophene and benzofuran derivatives having antiallergic activity are described as well as a method of manufacture, pharmaceutical compositions, and methods of use therefor. The disclosure describes the use of derivatives for prevention of the release of mediators including histamine and leukotrienes from basophils and mast cells, and prevent respiratory burst in neutrophils providing activity useful in cardiovascular disorders as well as in antiinflammatory, psoriasis, and antimigrane treatment. The novel compounds are of the general formula: Image wherein R1 to R5 and X are as defined in the disclosure and claims.

496926

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