Benzothiophenes and related compounds as estrogen agonists

Details Benzothiophenes and related compounds as estrogen agonists Benzothiophenes and related compounds as estrogen agonists

C - Chemistry, Metallurgy

07

D

C07D 409/00 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) C07D 307/79 (2006.01) C07D 333/54 (2006.01) C07D 333/56 (2006.01) C07D 335/06 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/00 (2006.01) C07D 409/04 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01) C07D 471/02 (2006.01) C07D 495/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2173243

Benzothiophenes and related compounds of formula (1), wherein A, B, Z are independently -CH=, -CR4= or =N-; X is -S-, -O-, -NH-, -NR2, -CH2-CH2-, -CH2- CH2-CH2-, -CH2-O-; -OCH2-, -CH2-S-, -CO-, -SCH2-, -N=CR2- or -R2C=N-; Y is optionally substituted phenyl, alkyl, cycloalkyl, cycloalkenyl, heterocycle or bicyclic ring system; D is -CO-, -CR2R3-, -CONH-, -NHCO-, -CR2(OH)-, -CONR2, NOR1 CH-NO2 N-CN -NR2-CO-, -C-, -C-, -C-; E is a single bond, optionally substituted phenyl, heterocycle; Z1 is -(CH2)p W(CH2)q-, -O(CH2)p CR5R6- or - O(CH2)p W(CH2)q; G is -NR7R8, (a), (b), (c), a 5- or 6-membered saturated, unsaturated or partially unsaturated and optionally substituted heterocycle or a bicyclic amine containing 5 to 12 carbon atoms either bridged or fused and optionally substituted and R is halogen, -NR2R3, -NHCOR2, -NHSO2R2, -CR2R3OH, - CONR2R3, -SO2NR2R3, OH, -OR1, -O-COR1; are estrogen agonists which are useful for treating syndromes and diseases caused by estrogen deficiency.

Benzothiophènes et composés associés de formule (1) agonistes des oestrogènes s'avérant utiles dans le traitement des syndromes et maladies dues aux déficiences en oestrogènes. Dans la formule (I), A, B, Z sont indépendamment -CH=, -CR¿4?= ou =N-; X est -S-, -O-, -NH-, -NR¿2?, -CH¿2?-CH¿2?-, -CH¿2?-CH¿2?-CH¿2?-, -CH¿2?-O-; -OCH¿2?-, -CH¿2?-S-, -CO-, -SCH¿2?-, -N=CR¿2?- or -R¿2?C=N-; Y est phényle, alkyle, cycloalkyle, cycloalcényle, un hétérocycle, ou un système bicyclique éventuellement substitué; D est -CO-, -CR¿2?R¿3?-, -CONH-, -NHCO-, -CR¿2?(OH)-, -CONR¿2?, NOR¿1? CH-NO¿2? N-CN -NR¿2?-CO-, -C-, -C-, -C-; E est une liaison simple, phényle éventuellement substitué, un hétérocycle; Z?1¿ est -(CH¿2?)¿p? W(CH¿2?)¿q?-, -O(CH¿2?)¿p? CR¿5?R¿6?- ou -O(CH¿2?)¿p? W(CH¿2?)¿q?; G est -NR¿7?R¿8?, la formule (a), la formule (b), la formule (c), un hétérocycle à 5 ou 6 chaînons saturé, insaturé ou partiellement saturé et éventuellement substitué, ou une amine bicyclique à 5 à 12 atomes de carbone pontée ou à anneaux condensés et éventuellement substitué, et R est halogène, -NR¿2?R¿3?, -NHCOR¿2?, -NHSO¿2?R¿2?, -CR¿2?R¿3?OH, -CONR¿2?R¿3?, -SO¿2?NR¿2?R¿3?, OH, -OR¿1?, -O-COR¿1?.

Affiliated with

Also associated with

Rating

Benzothiophenes and related compounds as estrogen agonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzothiophenes and related compounds as estrogen agonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzothiophenes and related compounds as estrogen agonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1616894