Benzothiopyrano(4,3-c)pyridazine compounds, methods for...

Details Benzothiopyrano(4,3-c)pyridazine compounds, methods for... Benzothiopyrano(4,3-c)pyridazine compounds, methods for...

C - Chemistry, Metallurgy

07

D

167/224, 260/264

C07D 495/04 (2006.01) A61K 31/50 (2006.01)

Patent

CA 1292740

ABSTRACT A benzothiopyrano[4,3-clpyridazine compound of the formula: Image (I) wherein R1 and R2 are the same or different and each is hydrogen, halogen, trifluoromethyl, hydroxy, amino, nitro, cyano, C1-4 alkyl, C1-4 alkoxy or C2-5 alkanoylamido, R3 is hydrogen, C1-10 alkyl, hydroxy-C1-4 alkyl, C2-5 alkanoyloxy- C1-4 alkyl, pyridyl, aryl, aryl-C1-4 alkyl, or substituted aryl or aryl-C1-4 alkyl by at least one substituent selected from the group consisting of halogen, trifluoromethyl, hydroxy, hydroxy, amino, nitro, cyano, C1-4 alkyl, C1-4 alkoxy and C2-5 alkanoylamido on the aromatic ring, n is 0, 1 or 2, and the bond ---- between the 4-position and the 4a-position is single bond or double bond, a method thereof and a use thereof. The compounds possess anti-anxietic activity and are useful as drugs.

539969

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