Benzoureas having anti-diabetic activity

Details Benzoureas having anti-diabetic activity Benzoureas having anti-diabetic activity

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/422 (2006.01) A61K 31/423 (2006.01) A61K 31/428 (2006.01) C07D 413/10 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2565803

Benzourea compounds of Formula I having aryl-(CH2)x-oxazolidinedione or aryl- (CH2)x-thiazolidinedione substituents on one of the N atoms of the benzourea ring, wherein x is 0 or 1, are PPAR gamma agonists or partial agonists and are useful in the treatment and control of type II diabetes, including hyperglycemia and other symptoms such as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity, that are often associated with type 2 diabetes.

L'invention concerne des composés de benzo-urée de formule I possédant des substituants d'aryl-(CH2)x-oxazolidinédione ou d'aryl-(CH2)x-thiazolidinédione sur un des N atomes de l'anneau de benzo-urée, x étant égal à 0 ou 1. Lesdits composés sont des agonistes PPAR gamma ou des agonistes partiels et sont utilisés dans le traitement et la régulation de diabète de type II, notamment, de l'hyperglycémie et d'autres symptômes, tels que la dyslipidémie, l'hyperlipidémie, l'hypercholestérolémie, l'hypertriglycéridémie et l'obésité qui sont souvent associées au diabète de type II.

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