C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 497/04 (2006.01) A61K 31/55 (2006.01) A61P 9/00 (2006.01) C07D 221/00 (2006.01) C07D 327/00 (2006.01)
Patent
CA 2398615
This invention provides novel benzoethers of formulae (I, II). These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders.
La présente invention concerne des nouveaux benzoéthers de formules suivantes (I & II). Ces composés sont utilisés en tant qu'antagonistes des canaux calcium dotés d'une activité cardio-vasculaire, antiasthmatique et antibronchoconstriction. De ce fait, l'invention se rapporte à des compositions pharmaceutiques ainsi qu'à des méthodes de prévention et de traitement des troubles du type hypersensibilité, allergie, asthme, bronchospasme, dysménorrhée, spasme oesophagien, glaucome, accouchement prématuré, troubles du tractus urinaire, troubles de la motilité gastro-intestinale et troubles cardio-vasculaires.
Bullington James R.
Dodd John H.
Hall Daniel A.
Henry James R.
Rupert Kenneth C.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ortho-Mcneil Pharmaceutical Inc.
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