Benzoxazepine compounds, their production and use as lipid...

Details Benzoxazepine compounds, their production and use as lipid... Benzoxazepine compounds, their production and use as lipid...

C - Chemistry, Metallurgy

07

D

C07D 267/14 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 491/10 (2006.01) C07D 491/113 (2006.01) C07D 521/00 (2006.01) C07F 9/6527 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2231052

This invention provides new benzox-azepine compounds represented by formula (I), wherein R stands for a lower alkyl group optionally substituted with a hydroxyl group, X stands for an optionally substituted car-bamoyl group or an optionally substituted het-erocyclic group having a deprotonatable hy-drogen atom, R1 stands for a lower alkyl group and W stands for a halogen atom having ac-tivities of lowering cholesterol-level and low-ering trigluceride-level, and being useful for prophylaxis and therapy of hyperlipidemia.

Cette invention se rapporte à de nouveaux composés de benzoxazépine, représentés par la formule (I), où R représente un groupe alkyle inférieur éventuellement substitué par un groupe hydroxyle, X représente un groupe carbamoyle éventuellement substitué ou un groupe hétérocyclique éventuellement substitué comportant un atome d'hydrogène déprotonable, R1 représente un groupe alkyle inférieur et W représente un atome d'halogène. De tels composés possèdent des activités d'abaissement du niveau de cholestérol et d'abaissement du niveau de triglycérides et ils sont utiles dans la prophylaxie et la thérapie de l'hyperlipidémie.

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