Benzoxazin-3-ones and derivatives thereof as inhibitors of pi3k

Details Benzoxazin-3-ones and derivatives thereof as inhibitors of pi3k Benzoxazin-3-ones and derivatives thereof as inhibitors of pi3k

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/538 (2006.01) A61P 29/00 (2006.01) C07D 403/06 (2006.01) C07D 413/06 (2006.01) C07D 413/14 (2006.01) C07D 417/06 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2508601

The present invention provides compounds of Formula (I) wherein W, Q, E, D, R6, R7, R8, Y, K, R9, R1O, R12, G, and the double bond denoted "*" have any of the values defined therefore in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (I). The compounds are inhibitors of phosphoinsitide-3-kinase (P13K).

La présente invention concerne des composés représentés par la formule (I), dans cette formule, W, Q, E, D, R?6¿, R?7¿, R?8¿, Y, K, R?9¿, R?1O¿, R?12¿, G et la double liaison indiquée "*" ont n'importe quelle valeur définie dans la spécification; l'invention concerne également des sels pharmaceutiquement acceptables de ces composés. Les composés et les sels décrits dans cette invention sont utilisés en tant qu'agents pour le traitement de maladies et d'affections, parmi lesquelles des maladies inflammatoires, des maladies cardio-vasculaires, et des cancers. En outre, cette invention concerne des compositions pharmaceutiques comprenant un ou plusieurs composés représentés par la formule (I). Ces composés sont des inhibiteurs de la phosphoinsitide-3-kinase (P13K).

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