Benzoxazine derivatives, their preparation, and their...

C - Chemistry – Metallurgy – 07 – D

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C07D 265/36 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07D 413/02 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2117122

ABSTRACT BENZOXAZINE DERIVATIVES, THEIR PREPARATION, AND THEIR APPLICATION IN THERAPY Compounds of the formula: Image (I) in which Y represents hydrogen, fluorine, chlorine, methyl or methoxy, R1 represents phenyl substituted by fluorine, methyl, methoxy, trifluoromethyl or phenyl, or R1 represents 2-thienyl, R2 represents methyl, and R3 represents (C1-C4)-alkyl, or phenyl-(C1-C2)-alkyl optionally substituted on the ring by 2 to 3 methoxy groups, or 2-(2-pyridyl)ethyl, or R2 and R3 form, with the adjacent nitrogen, 4-phenyl(1-piperidyl), 4-phenylmethyl(1-piperidyl), 1,2,3,4-tetrahydro- 2-isoquinolyl, 6-methoxy-1,2,3,4-tetrahydro- 2-isoquinolyl, 5,8-dimethoxy-1,2,3,4-tetrahydro- 2-isoquinolyl, 6,7-dimethoxy- 1,2,3,4-tetrahydro-2-isoquinolyl, 2,3,4,5-tetrahydro- 1H-3-benzazepin-3-yl, or 7,8-dimethoxy- 2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl, and X represents carbonyl or sulphonyl, and their salts are useful as neuroprotective and antiiischaemic agents.

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