Benzoxazines and derivatives thereof as inhibitors of pi3ks

Details Benzoxazines and derivatives thereof as inhibitors of pi3ks Benzoxazines and derivatives thereof as inhibitors of pi3ks

C - Chemistry, Metallurgy

07

D

C07D 417/06 (2006.01) A61K 31/538 (2006.01) A61K 31/553 (2006.01) A61P 29/00 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2510851

The present invention provides compounds of Formula (I) wherein W, Q, E, D, A, L, R6, R7, R8, Y, K, R9, R10, G, the dashed bond between D and E, and the double bond denoted "*" have any of the values defined therefore in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (I).

La présente invention a trait à des dérivés de formule (I) dans laquelle : W, Q, E, D, A, L, R?6¿, R?7¿, R?8¿, Y, K, R?9¿, R?10¿,? ¿G, et la liaison en pointillé entre D et E, et la double liaison désignée <=*>= sont tels que définis dans la description, et leurs sels pharmaceutiquement acceptables, qui sont utiles en tant qu'agents dans le traitement de maladies et de conditions, comprenant les maladies inflammatoires, les maladies cardio-vasculaires, et les cancers. L'invention a également trait à des compositions pharmaceutiques comportant un ou des composés de formule (I).

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