C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 265/36 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 279/16 (2006.01)
Patent
CA 2319551
This invention discloses benzoxazinone and benzothiazinone compounds which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnormal thrombosis.
L'invention concerne des composés de benzoxazinone et de benzothiazinone qui ont des effets inhibiteurs sur des sérines-protéases telles que le facteur Xa, la thrombine et/ou le facteur VIIa. L'invention concerne également des sels pharmaceutiquement acceptables de ces composés, des compositions pharmaceutiquement acceptables contenant ces composés ou leurs sels, ainsi que des méthodes pour les utiliser comme agents thérapeutiques pour traiter ou prévenir chez des mammifères des états pathologiques caractérisés par une thrombose anormale.
Berryman Kent Alan
Downing Dennis Michael
Dudley Danette Andrea
Edmunds Jeremy John
Narasimhan Lakshmi Sourirajan
Macrae & Co.
Warner-Lambert Company
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