C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 267/22 (2006.01) A61K 31/395 (2006.01) A61P 25/04 (2006.01)
Patent
CA 2600254
A compound selected from (1 S)-8-cyano-5-methyl-1-(3-methoxy)phenyl-1,3,4,6- tetrahydro-5H-benz[f]-2,5- oxazocine; (1 R)-8-cyano-5-methyl-1-(3- methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5- oxazocine; (1 S)-8- cyclopropyl-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]- 2,5- oxazocine; (1 S)-8-cyclopropyl-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro- 5H-benz[f]-2,5-oxazocine; (1 S)-5-methyl-1-(3-methoxy)phenyl-1 ,3,4,6- tetrahydro-5H-benz[f]-2,5- oxazocine-8-carboxamide; (1 R)-5-methyl-1-(3- methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5- oxazocine-8-carboxamide; and the salts thereof. These compounds have therapeutic utility.
L~invention concerne un composé choisi parmi la (1S)-8-cyano-5-méthyl-1-(3-méthoxy)phényl-1,3,4,6-tétrahydro-5H-benz[f]-2,5-oxazocine ; la (1R)-8-cyano-5-méthyl-1-(3-méthoxy)phényl-1,3,4,6-tétrahydro-5H-benz[f]-2,5-oxazocine ; la (1S)-8-cyclopropyl-5-méthyl-1-(3-méthoxy)phényl-1,3,4,6-tétrahydro-5H-benz[f]-2,5-oxazocine ; la (1S)-8-cyclopropyl-5-méthyl-1-(3-méthoxy)phényl-1,3,4,6-tétrahydro-5H-benz[f]-2,5-oxazocine ; le (1S)-5-méthyl-1-(3-méthoxy)phényl-1,3,4,6-tétrahydro-5H-benz[f]-2,5-oxazocine-8-carboxamide; le (1R)-5-méthyl-1-(3-méthoxy)phényl-1,3,4,6-tétrahydro-5H-benz[f]-2,5-oxazocine-8-carboxamide ; et leurs sels. Ces composés ont une utilité thérapeutique.
Sosei R&d Ltd.
Torys Llp
LandOfFree
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