Benzoxazole carboxamides for treating cinv and ibs-d

Details Benzoxazole carboxamides for treating cinv and ibs-d Benzoxazole carboxamides for treating cinv and ibs-d

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/423 (2006.01) A61P 1/06 (2006.01) A61P 1/08 (2006.01) C07D 451/04 (2006.01) C07D 451/14 (2006.01) C07D 453/02 (2006.01) C07D 498/08 (2006.01)

Patent

CA 2597962

Compounds of formulae (I) and (II) are disclosed as 5-HT3inhibitors. Those compounds that exhibit central activity are useful in treating chemotherapy- induced nausea and vomiting (CINV); those that peripheral receptors are useful to treat diarrhea-predominant Irritable Bowel Syndrome (IBS-D).

L'invention porte sur des composés de formule (I) et (II), inhibiteurs du 5-HT3 . Lesdits composés, qui présentent une activité centrale, s'avèrent utiles pour traiter les nausées et vomissements dus à la chimiothérapie (CINV); et ceux qui présentent des récepteurs périphériques, le syndrome de l'intestin irritable à prédominance diarrhée (IBS-D).

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