C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/311.1, 260/3
C07D 413/04 (2006.01) C07D 263/56 (2006.01) C07D 263/57 (2006.01) C07D 317/50 (2006.01)
Patent
CA 1042903
ABSTRACT OF THE DISCLOSURE Novel benzoxazole derivatives of formula I Image I wherein the group -CR1R2R3 is in the 5- or 6- position of the benzoxazole nucleus, R4 is a phenyl group optionally substituted in any position by one or more C1-6 alkylsulphonyl, halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, nitro, C2-7 acyl, hydroxy, amino, C1-6 alkylamino or C2-7 acylamino groups or optionally substituted in two adjacent positions by methylene- or ethylene-dioxy, R1 is hydrogen or C1-6 alkyl, R2 is hydrogen and R3 is a nitrile or carboxy group, or a salt, ester, amide or hydroxamic acid derivative thereof, are described. Also described is a process for preparing such compounds, comprising reducing a compound of formula I above wherein R1, R3 and R4 are as defined above, and R2 is halogen, hydroxy or C2-7 acyloxy. These compounds possess analgesic, antipyretic and/or anti-inflammatory activity, or are useful an intermediates for the preparation of compounds which do have such activity.
211959
Dunwell David W.
Evans Delme
Hicks Terence A.
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