Benzoxazole kinase inhibitors and methods of use

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2741898

The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases such as mTor, tyrosine kinases, and/or lipid kinases such as P13 kinase. Also provided in the present invention are methods of using these compositions to modulate activities of one or more of these kinases, especially for therapeutic applications.

La présente invention porte sur des entités ou sur des composés chimiques et sur de compositions pharmaceutiques de ceux-ci qui sont aptes à moduler certaines kinases de protéine telles que mTor, les kinases de tyrosine et/ou les kinases de lipide telles que la PI3 kinase. La présente invention porte également sur des procédés d'utilisation de ces compositions pour moduler des activités d'une ou plusieurs de ces kinases, en particulier pour des applications thérapeutiques.

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