C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/044 (2006.01) A61K 31/553 (2006.01) A61P 37/08 (2006.01)
Patent
CA 2521831
A process for the production of acid addition salts of 3-[4-(8-fluoro-5,11- dihydrobenz[b]oxepino[4,3-b]pyridin-11- ylidene)piperidino]propionic acid alkyl esters, characterized by reacting alkyl 3-[4-(8-fluoro-5,11- dihydrobenz[b]oxepino- [4,3-b]pyridin-11-ylidene)piperidino]propionate with an acid; and a process for the production of 3-[4-(8-fluoro-5,11- dihydrobenz[b]oxepino[4,3-b]pyridin-11-ylidene)piperidino]-propionic acid by using the above acid addition salt as the intermediate.
La présente invention concerne un procédé de production de sels d'addition acide d'esters d'alkyle acide propionique 3-[4-(8-fluoro-5,11-dihydrobenz[b]oxépino[4,3-b]pyridin-11-ylidène)pipéridino], qui se caractérise en ce qu'on fait réagir avec un acide, de l'alkyle 3-[4-(8-fluoro-5,11-dihydrobenz[b]oxépino-[4,3-b]pyridin-11-ylidène)pipéridino]propionate. Cette invention porte également sur un procédé de production d'acide propionique 3-[4-8-fluoro-5,11-dihydrobenz[b]oxépino[4,3-b]pyrindin-11-ylidène)pipéridino] dans lequel on utilise en tant qu'intermédiaire, ledit sel d'addition acide.
Inoue Tsutomu
Sasaki Tomomitsu
Sato Takahiro
Uda Junichiro
Fujiyakuhin Co. Ltd.
Gowling Lafleur Henderson Llp
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