C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/24 (2006.01) A61K 31/4439 (2006.01) A61K 31/497 (2006.01) A61P 3/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)
Patent
CA 2667316
The invention relates to a novel group of compounds of Formula (I) or a salt thereof: wherein R1, R2, R3, n, A and HET-1 are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through glucokinase (GLK) such as type 2 diabetes. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by GLK using said compounds and methods for preparing compounds of Formula (I).
L'invention concerne un nouveau groupe de composés de formule (I) ou un sel de ceux-ci : (dans la formule, R1, R2, R3, n, A et HET-1 sont tels que décrits dans la description), lesquels peuvent être utiles dans le traitement ou la prévention d'une maladie ou affection médicale médiée par la glucokinase (GLK) telle que le diabète de type 2. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés, des procédés de traitement de maladies médiées par la GLK utilisant lesdits composés et des procédés servant à préparer les composés de formule (I).
Martin Nathaniel George
Mckerrecher Darren
Pike Kurt Gordon
Waring Michael James
Astrazeneca Ab
Fetherstonhaugh & Co.
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