Benzoyl-piperidine derivatives as dual modulators of the...

Details Benzoyl-piperidine derivatives as dual modulators of the... Benzoyl-piperidine derivatives as dual modulators of the...

C - Chemistry, Metallurgy

07

D

C07D 211/32 (2006.01)

Patent

CA 2694057

The present invention relates to compounds of the general Formula (I) wherein R1 and A are as defined in the specifica-tion as dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use as medicaments. Compounds of general Formula (I) have high affinity for the dopamine D3 and serotonin (5-Hydrox-ytryptamine; 5-HT) 5-HT2A receptors and are effective in the treat-ment of psychotic disorders, as well as other diseases such as depres-sion and anxiety, drug dependence, dementias and memory impair-

La présente invention porte sur des composés représentés par la Formule générale (I) dans laquelle R1 et A sont tels que définis dans la description comme modulateurs doubles des récepteurs de la sérotonine 5-HT2a et D3 de la dopamine. L'invention porte également sur la fabrication de ces composés, sur des compositions pharmaceutiques les contenant et sur leur utilisation comme médicaments. Les composés de la Formule générale (I) ont une haute affinité pour les récepteurs D3 de la dopamine et 5-HT2A (5-hydroxytryptamine ; 5-HT) de la sérotonine et sont efficaces dans le traitement de troubles psychotiques, ainsi que d'autres maladies telles que la dépression et l'anxiété, la dépendance vis-à-vis des médicaments, les démences et la défaillance de la mémoire.

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