Benzoylpropionic acid ester derivatives

Details Benzoylpropionic acid ester derivatives Benzoylpropionic acid ester derivatives

C - Chemistry, Metallurgy

07

C

C07C 229/36 (2006.01) A61K 31/215 (2006.01) C07C 227/22 (2006.01)

Patent

CA 2258074

Benzoylpropionic acid ester derivatives of formula (I) wherein R is C1-C4 alkyl or benzyl, and the pharmaceutically acceptable salts thereof, which act as kynurenine-3-hydroxylase enzyme inhibitors and are useful in the treatment of neurodegenerative diseases. A process for preparing compounds of formula (I) and pharmaceutical compositions comprising them are also described.

Cette invention se rapporte à des dérivés d'esters d'acide benzoylpropionique représentés par la formule (I), où R représente alkyle C¿1?-C¿4? ou benzyle, et aux sels de ces dérivés acceptables sur le plan pharmaceutique, qui agissent comme inhibiteurs de l'enzyme kynurénine-3-hydroxylase et sont utiles dans le traitement des maladies neuro-dégénératives. Cette invention présente également un procédé pour préparer des composés représentés par la formule (I) et des compositions pharmaceutiques comprenant ces composés.

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