C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 33/50 (2006.01) A61K 31/045 (2006.01) A61K 31/075 (2006.01) A61K 31/35 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/45 (2006.01) A61K 31/695 (2006.01) C07C 33/46 (2006.01) C07C 33/48 (2006.01) C07C 43/178 (2006.01) C07C 43/23 (2006.01) C07C 69/78 (2006.01) C07C 69/92 (2006.01) C07D 207/40 (2006.01) C07D 207/404 (2006.01) C07D 209/48 (2006.01) C07D 211/88 (2006.01) C07D 213/64 (2006.01) C07D 309/12 (2006.01) C07F 7/08 (2006.01)
Patent
CA 2304274
The invention relates to benzyl-biphenyls and analogous compounds thereof which are produced first by reacting .alpha. and .beta.-unsaturated ketones to form corresponding substituted and conjugated dienes, and afterwards said dienes are cyclized with acetylene derivatives. The resulting cyclohexane dienes are oxidized to form aromatic compounds and/or are varied in available substituents through usual methods. The compounds are suited for additives in medicaments, especially in medicaments for treating arteriosclerosis and dyslipidaemia.
L'invention concerne des benzylbiphényles et des composés analogues, produit selon un procédé consistant tout d'abord à faire réagir des cétones .alpha. et .beta. insaturées pour former des diènes conjugués, substitués de façon correspondante, puis à cycliser ces derniers avec des dérivés d'acétylène, à oxyder les cyclohexanediènes ainsi obtenus pour former des composés aromatiques, et le cas échéant à les faire varier dans les substituants présents, selon des méthodes usuelles. Les composés de l'invention s'utilisent comme principes actifs dans des médicaments, notamment dans des médicaments servant à traiter l'artériosclérose et les dyslipidémies.
Bischoff Hilmar
Brandes Arndt
Bremm Klaus-Dieter
Logers Michael
Schmidt Delf
Aktiengesellschaft Bayer
Fetherstonhaugh & Co.
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