Benzyl-cycloalkyl sphingosine 1-phosphate receptor modulators

Details Benzyl-cycloalkyl sphingosine 1-phosphate receptor modulators Benzyl-cycloalkyl sphingosine 1-phosphate receptor modulators

C - Chemistry, Metallurgy

07

C

C07C 211/16 (2006.01) C07C 211/21 (2006.01) C07C 211/27 (2006.01) C07C 211/33 (2006.01)

Patent

CA 2700977

Sphingosine-1 -phosphate analogs that are potent, and selective agonists at one or more SIP receptors, specifically the SIP, receptor type are provided. The disclosed compounds include an optional phosphate moiety as well as compounds with hydrolysis-resistant phosphate surrogates such as phosphonates, alpha- substituted phosphonates, and phosphothionates. Image

La présente invention concerne des analogues du sphingosine 1-phosphate (S1P) qui sont puissants, et des agonistes sélectifs pour un ou des récepteurs du S1P, en particulier le récepteur de type S1P1. Les composés décrits comprennent un groupement phosphate facultatif ainsi que des composés avec des substituants phosphates résistants à l'hydrolyse tels que les phosphonates, les phosphonates alpha-substitués, et les phosphothionates.

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