Benzyl-pyridazinons as reverse transcriptase inhibitors

Details Benzyl-pyridazinons as reverse transcriptase inhibitors Benzyl-pyridazinons as reverse transcriptase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 237/14 (2006.01) A61K 31/50 (2006.01) A61K 31/501 (2006.01) A61P 31/18 (2006.01) C07D 237/22 (2006.01) C07D 401/12 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2518823

This invention relates to novel pyridazinone derivatives of formula (I) wherein R1-R4, R7, R8 and X1 are as defined in the summary and pharmaceutically acceptable salts and solvates thereof, methods to inhibit or modulate Human Immunodeficiency Virus (HIV) reverse transcriptase with compounds of formula (I), pharmaceutical compositions containing of formula (I) admixed with at least one solvent, carrier or excipient and processes to prepare compounds of formula (I). The compounds are useful for treating disorders in which HIV and genetically related viruses are implicated.

L'invention concerne des dérivés de pyridazinone de formule (I), dans laquelle R?1¿-R?4¿, R?7¿, R?8¿ et X?1¿ sont tels que définis dans la description, y compris leurs sels et solvates pharmaceutiquement acceptables. L'invention concerne également des procédés relatifs à l'inhibition ou à la modulation de la transcriptase inverse du VIH par le biais des composés décrits, ainsi que des compositions pharmaceutiques renfermant les composés en question mélangés avec au moins un solvant, un vecteur ou un excipient, et des procédés relatifs à l'élaboration des composés considérés. Il s'agit de composés utiles pour le traitement des troubles dans lesquels interviennent le VIH et les virus génétiquement apparentés.

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