Benzylamine derivatives and their use as thrombin inhibitors

Details Benzylamine derivatives and their use as thrombin inhibitors Benzylamine derivatives and their use as thrombin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/44 (2006.01) A61K 31/4439 (2006.01) A61P 9/00 (2006.01) C07D 205/04 (2006.01) C07D 207/16 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07K 5/06 (2006.01) C07K 5/062 (2006.01) C07K 5/065 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2431588

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, e.g. where R3 is -CH2NH2, -CH2CH2NH2, or - CH2NHC(O)OC(CH3)3.

L'invention porte sur des composés qui sont utiles dans l'inhibition de la thrombine et sur des occlusions thrombotiques associées ayant la structure suivante dans laquelle R<3> représente -CH2NH2, -CH2CH2NH2, ou -CH2NHC(O)OC(CH 3)3, ou sur un sel de ces composés acceptables d'un point de vue pharmaceutique.

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