C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/02 (2006.01) A61K 31/44 (2006.01)
Patent
CA 2546142
The present invention is directed to benzylether and benzylamino derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta- secretase enzyme is involved.
L'invention concerne des composés de dérivés de benzylether et benzylamino inhibiteurs de l'enzyme bêta-sécrétase et utiles pour traiter des maladies dans lesquelles cette enzyme joue un rôle, telles que la maladie d'Alzheimer. Elle concerne également des compositions pharmaceutiques contenant ces composés, ainsi que l'utilisation de ces composés et de ces compositions pour traiter des maladies dans lesquelles l'enzyme bêta-sécrétase joue un rôle.
Nantermet Philippe G.
Rajapakse Hemaka A.
Selnick Harold G.
Stauffer Shaun R.
Young Mary Beth
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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