Benzylglycosylamides as inhibitors of smooth muscle cell...

Details Benzylglycosylamides as inhibitors of smooth muscle cell... Benzylglycosylamides as inhibitors of smooth muscle cell...

C - Chemistry, Metallurgy

07

H

C07H 13/04 (2006.01) A61K 31/70 (2006.01) A61P 9/00 (2006.01) A61P 21/00 (2006.01) A61P 35/00 (2006.01) C07H 13/08 (2006.01) C07H 13/10 (2006.01) C07H 15/18 (2006.01)

Patent

CA 2350758

This invention provides smooth muscle cell proliferation inhibitors of formula (I) having a structure wherein Y is C or N; where n is 0 - 3; X is (A) wherein R1, and R2 are each independently, hydrogen, alkyl of 1 to 6 carbon atoms, halo, acetyl, phenyl, CF3, CN, OH, NO2, NH2, alkoxy of 1 to 6 carbon atoms, or alkoxynitrile of 1 to 6 carbon atoms; R3 is hydrogen, acylamide of 2 to 6 carbon atoms or alkoxy of 1 to 6 carbon atoms; R4, R5, R6, R7 and R8 are each, independently, hydrogen, acyl of 1 to 6 carbon atoms, benzyl substituted with R1, and R2; or benzoyl substituted with R1 and R2; R9 and R10 are each, independently, acyl of 1 to 6 carbon atoms, or the R9 and R10 groups on the 4' and 6' positions of the maltose may be taken together to form a cyclic acetal which may be substituted with alkyl of 1 to 6 carbon atoms, two alkyl groups each having 1 to 6 carbon atoms, pyridine substituted with R1, phenyl substituted with R1, benzyl substituted with R1, 2-phenylethyl substituted with R1, or 3-phenylpropyl substituted with R1; or a pharmaceutically acceptable salt thereof.

Cette invention concerne des inhibiteurs de prolifération des cellules du muscle lisse, ou un sel pharmaceutiquement acceptable desdits inhibiteurs, qui présentent une structure de la formule (I) dans laquelle Y est C ou N; n est compris entre 0 et 3; X est représenté par la formule (A); R?1¿ et R?2¿ sont chacun, indépendamment de l'autre, hydrogène, un alkyle comprenant 1 à 6 atomes de carbone, halo, acétyle, phényle, CF¿3?, CN, OH, NO¿2?, NH¿2?, un alcoxy comprenant 1 à 6 atomes de carbone, ou un alcoxynitrile comprenant 1 à 6 atomes de carbone; R?3¿ est hydrogène, un acylamide comprenant 2 à 6 atomes de carbone ou un alcoxy comprenant 1 à 6 atomes de carbone; R?4¿, R?5¿, R?6¿, R?7¿ et R?8¿ sont chacun, indépendamment des autres, hydrogène, un acyle comprenant 1 à 6 atomes de carbone, benzyle substitué par R?1¿ et R?2¿, ou benzoyle substitué par R?1¿ et R?2¿; R?9¿ et R?10¿ sont chacun, indépendamment de l'autre, un acyle comprenant 1 à 6 atomes de carbone, ou les groupes R?9¿ et R?10¿ aux positions 4' et 6' du maltose peuvent être pris ensemble pour former un acétal cyclique pouvant être substitué par un alkyle comprenant 1 à 6 atomes de carbone, deux groupes alkyle ayant chacun entre 1 et 6 atomes de carbone, pyridine substitué par R?1¿, phényle substitué par R?1¿, benzyle substitué par R?1¿, 2-phényléthyle substitué par R?1¿, ou 3-phénylpropyle substitué par R?1¿.

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